H Pylori in Humans : Where are We Now
Abstract
H. pylori has been associated with humans for millions of years and its association with gastro duodenal diseases has well been established. Research explosion has added vastly to the current dimensions. The new and unusual pattern of involvement in the form of diffuse duodenal nodular lymphoid hyperplasia (DDNLH) due to specific strain of H. pylori has been reported from Kashmir recently, which heckles early recognition and treatment and on the other hand, we continue to face challenges so for as the prevention of ca- stomach, a worst sequelae of H. pylori is concerned, although population screening and prevention surveys are underway in many countries. Continued scientific work has now unfolded involvement of H.pylori in extra gastric diseases like Cerebrovascular, cardiovascular, idiopathic thrombocytopenia, sideroblastic anaemia, mental diseases, collagen vascular disease. Moreover the beneficial effects of H. pylori with respect to allergic diseases and obesity are clear. Problem of drug resistance for eradication of H. pylori has arisen for which novel treatments are tried. Lactobacillus reuteri having ant H.pylori action is one of the promising treatment as is now available in India for usage. The main challenges which remain are prevention of H. pylori related diseases by effective treatment and screening procedures and development of a vaccine which can address all these issues including beneficial aspects of H. pylori.
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